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Literature summary for 2.5.1.112 extracted from
- Binding and catalysis of Humulus lupulus adenylate isopentenyltransferase for the synthesis of isopentenylated diadenosine polyphosphates (2010), FEBS Lett., 584, 4083-4088.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Humulus lupulus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dimethylallyl diphosphate + ADP | Humulus lupulus | - |
diphosphate + N6-(dimethylallyl)adenosine 5'-diphosphate | - |
? |  |
| dimethylallyl diphosphate + ATP | Humulus lupulus | - |
diphosphate + N6-(dimethylallyl)adenosine 5'-triphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Humulus lupulus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dimethylallyl diphosphate + ADP | - |
Humulus lupulus | diphosphate + N6-(dimethylallyl)adenosine 5'-diphosphate | - |
? | |
| dimethylallyl diphosphate + ATP | - |
Humulus lupulus | diphosphate + N6-(dimethylallyl)adenosine 5'-triphosphate | - |
? | |
| dimethylallyl diphosphate + ATP | ATP is the best cosubstrate | Humulus lupulus | diphosphate + N6-(dimethylallyl)adenosine 5'-triphosphate | - |
? | |
| dimethylallyl diphosphate + diadenosine hexaphosphate | - |
Humulus lupulus | ? | - |
? | |
| dimethylallyl diphosphate + diadenosine pentaphosphate | diadenosine pentaphosphate exhibits the highest binding affinity | Humulus lupulus | ? | - |
? | |
| dimethylallyl diphosphate + diadenosine tetraphosphate | - |
Humulus lupulus | ? | - |
? | |
| dimethylallyl diphosphate + diadenosine triphosphate | diadenosine pentaphosphate exhibits the lowest binding affinity and specific activity compared to ATP | Humulus lupulus | ? | - |
? | |
| additional information | no activity with NAD+, NADP+ or FAD | Humulus lupulus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| adenylate isopentenyltransferase | - |
Humulus lupulus |
| IPT | - |
Humulus lupulus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Humulus lupulus | |
| ATP | - |
Humulus lupulus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the isopentenyltransferase reaction is the key rate-limiting step in cytokinin biosynthesis | Humulus lupulus |
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Release 2023.1 (January 2023)
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