Literature summary for 2.5.1.111 extracted from

Wang, J.; Chen, C.C.; Yang, Y.; Liu, W.; Ko, T.P.; Shang, N.; Hu, X.; Xie, Y.; Huang, J.W.; Zhang, Y.; Guo, R.T.
Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis (2018), Biochem. Biophys. Res. Commun., 495, 1782-1788 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Fischerella ambigua

Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting drop vapor diffusion method, using 1.0 M sodium citrate, 0.1 M imidazole, pH 8.0	Fischerella ambigua

Organism

Organism	UniProt	Comment	Textmining
Fischerella ambigua	A0A1J0AKI6	-	-
Fischerella ambigua UTEX 1903	A0A1J0AKI6	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography	Fischerella ambigua

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dimethylallyl diphosphate + (2Z)-3-(1H-indol-3-yl)prop-2-enenitrile	dimethylallyl diphosphate is preferred over geranyl diphosphate	Fischerella ambigua	diphosphate + (2E)-3-[2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]prop-2-enenitrile + (2E)-3-[2-(3-methylbut-2-en-1-yl)-3H-indol-3-yl]prop-2-enenitrile	-	?
dimethylallyl diphosphate + (2Z)-3-(1H-indol-3-yl)prop-2-enenitrile	dimethylallyl diphosphate is preferred over geranyl diphosphate	Fischerella ambigua UTEX 1903	diphosphate + (2E)-3-[2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]prop-2-enenitrile + (2E)-3-[2-(3-methylbut-2-en-1-yl)-3H-indol-3-yl]prop-2-enenitrile	-	?
dimethylallyl diphosphate + hapalindole U	-	Fischerella ambigua	diphosphate + ambiguine H	-	?
dimethylallyl diphosphate + hapalindole U	-	Fischerella ambigua UTEX 1903	diphosphate + ambiguine H	-	?
geranyl diphosphate + (2Z)-3-(1H-indol-3-yl)prop-2-enenitrile	dimethylallyl diphosphate is preferred over geranyl diphosphate	Fischerella ambigua	diphosphate + (2Z)-3-(2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl)prop-2-enenitrile + (2E)-3-(2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3H-indol-3-yl)prop-2-enenitrile	-	?
geranyl diphosphate + (2Z)-3-(1H-indol-3-yl)prop-2-enenitrile	dimethylallyl diphosphate is preferred over geranyl diphosphate	Fischerella ambigua UTEX 1903	diphosphate + (2Z)-3-(2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl)prop-2-enenitrile + (2E)-3-(2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3H-indol-3-yl)prop-2-enenitrile	-	?

Synonyms

Synonyms	Comment	Organism
apT	-	Fischerella ambigua
aromatic prenyltransferase	-	Fischerella ambigua
FamD1	-	Fischerella ambigua

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Release 2023.1 (January 2023)