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Literature summary for 2.5.1.10 extracted from

  • Fernandez, D.; Ramis, R.; Ortega-Castro, J.; Casasnovas, R.; Vilanova, B.; Frau, J.
    New insights into human farnesyl pyrophosphate synthase inhibition by second-generation bisphosphonate drugs (2017), J. Comput. Aided Mol. Des., 31, 675-688 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alendronate
-
Homo sapiens
APHBP
-
Homo sapiens
neridronate
-
Homo sapiens
pamidronate
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14324
-
-

Synonyms

Synonyms Comment Organism
farnesyl pyrophosphate synthase
-
Homo sapiens
hFPPS
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00026
-
alendronate pH and temperature not specified in the publication Homo sapiens
0.000352
-
pamidronate pH and temperature not specified in the publication Homo sapiens
0.000388
-
neridronate pH and temperature not specified in the publication Homo sapiens
0.00298
-
APHBP pH and temperature not specified in the publication Homo sapiens