Literature summary for 2.5.1.10 extracted from

Huang, C.H.; Gabelli, S.B.; Oldfield, E.; Amzel, L.M.
Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer (2010), Proteins, 78, 888-899.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with substrate isopentenyl diphosphate and five nitrogen-containing bisphosphonate inhibitors. The C1-hydroxyl and the nitrogen-containing groups of the inhibitors alter the binding of isopentenyl diphosphate and the conformation of residues Y94 and Q167. binding of the inhibitors changes the binding properties of the second site of the dimer	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	Q8WS25	-	-

Subunits

Subunits	Comment	Organism
dimer	crystallization data	Trypanosoma cruzi

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Release 2023.1 (January 2023)