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Literature summary for 2.5.1.1 extracted from

  • Park, J.; Zielinski, M.; Magder, A.; Tsantrizos, Y.S.; Berghuis, A.M.
    Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product (2017), Nat. Commun., 8, 14132 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.1

Cloned(Commentary)

Cloned (Comment) Organism
the enzyme with an N-terminal His6 tag is transformed into Escherichia coli BL21 (DE3) cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
vapour diffusion in a sitting drop at 22°C. Crystalized in the presence of farnesyl diphosphate, and its X-ray structure is determined at 1.9 A resolution Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
farnesyl diphosphate allosteric product inhibition. the product can trap the enzyme in an unreactive state by binding to its allosteric pocket Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dimethylallyl diphosphate + isopentenyl diphosphate Homo sapiens the enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate diphosphate + geranyl diphosphate
-
 ?
geranyl diphosphate + isopentenyl diphosphate Homo sapiens reaction of EC 2.5.1.10. The enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate diphosphate + (2E,6E)-farnesyl diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14324
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylallyl diphosphate + isopentenyl diphosphate the enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate Homo sapiens diphosphate + geranyl diphosphate
-
 ?
geranyl diphosphate + isopentenyl diphosphate reaction of EC 2.5.1.10. The enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate Homo sapiens diphosphate + (2E,6E)-farnesyl diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
FPPS
-
 Homo sapiens