Literature summary for 2.5.1.1 extracted from

Pockrandt, D.; Li, S.M.
Geranylation of cyclic dipeptides by the dimethylallyl transferase AnaPT resulting in a shift of prenylation position on the indole ring (2013), ChemBioChem, 14, 2023-2028.

Search for more literature for 2.5.1.1

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dimethylallyl diphosphate + isopentenyl diphosphate	Aspergillus fischeri	-	diphosphate + geranyl diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Aspergillus fischeri	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dimethylallyl diphosphate + (R)-benzodiazepinedione	-	Aspergillus fischeri	aszonalenin + diphosphate	-	?
dimethylallyl diphosphate + isopentenyl diphosphate	-	Aspergillus fischeri	diphosphate + geranyl diphosphate	-	?
geranyl diphosphate + (3S)-3-(1H-indol-3-ylmethyl)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione	-	Aspergillus fischeri	(3S)-3-([6-[(2Z)-2-ethylidene-6-methylhept-5-en-1-yl]-1H-indol-3-yl]methyl)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione + (3S)-3-([7-[(2Z)-7-methylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione + diphosphate	31% + 60% yield	?
geranyl diphosphate + (3S,6R)-3-(4-hydroxybenzyl)-6-(1H-indol-3-ylmethyl)piperazine-2,5-dione	-	Aspergillus fischeri	(3R,6S)-3-([6-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione + (3R,6S)-3-([7-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione + diphosphate	32% + 13% yield	?
geranyl diphosphate + (3S,6S)-3,6-bis(1H-indol-3-ylmethyl)piperazine-2,5-dione	-	Aspergillus fischeri	(3S,6S)-3-([6-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(1H-indol-3-yl)methyl]piperazine-2,5-dione + (3S,6S)-3-([7-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(1H-indol-3-yl)methyl]piperazine-2,5-dione + diphosphate	15% + 35% yield	?
geranyl diphosphate + (3S,6S)-3-(1H-indol-3-ylmethyl)-6-(2-methylpropyl)piperazine-2,5-dione	-	Aspergillus fischeri	(3S,6S)-3-([6-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-(2-methylpropyl)piperazine-2,5-dione + (3S,6S)-3-([7-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-(2-methylpropyl)piperazine-2,5-dione + diphosphate	15% + 57% yield	?
geranyl diphosphate + (3S,6S)-3-(4-hydroxybenzyl)-6-(1H-indol-3-ylmethyl)piperazine-2,5-dione	-	Aspergillus fischeri	(3R,6R)-3-([6-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione + (3S,6S)-3-([7-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-1H-indol-3-yl]methyl)-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione + diphosphate	9% + 24% yield	?
geranyl diphosphate + (R)-benzodiazepinedione	-	Aspergillus fischeri	(3R)-3-([6-[(2Z)-2-ethylidene-6-methylhept-5-en-1-yl]-1H-indol-3-yl]methyl)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione + diphosphate	88% yield	?

Synonyms

Synonyms	Comment	Organism
AnaPT	-	Aspergillus fischeri
dimethylallyl transferase	-	Aspergillus fischeri

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Release 2023.1 (January 2023)