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Literature summary for 2.4.99.20 extracted from
- ADP-ribosyl cyclase and CD38. Multi-functional enzymes in Ca+2 signaling (1997), Adv. Exp. Med. Biol., 419, 411-419.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| enzyme is a dimer | Aplysia californica |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aplysia californica | P29241 | - |
- |
| Homo sapiens | P28907 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2'-phospho-cyclic ADP-ribose + nicotinate | - |
Homo sapiens | nicotinate-adenine dinucleotide phosphate | - |
? |  |
| 2'-phospho-cyclic ADP-ribose + nicotinate | - |
Aplysia californica | nicotinate-adenine dinucleotide phosphate | - |
? | |
| additional information | enzymes cyclizes NAD to cADPR. In the presence of nicotinic acid, it catalyzes a base exchange reaction resulting in the synthesis of nicotinate-adenine dinucleotide phosphate from NADP+. The switch between these two modes of catalysis is regulated by pH | Homo sapiens | ? | - |
? | |
| additional information | enzymes cyclizes NAD to cADPR. In the presence of nicotinic acid, it catalyzes a base exchange reaction resulting in the synthesis of nicotinate-adenine dinucleotide phosphate from NADP+. The switch between these two modes of catalysis is regulated by pH | Aplysia californica | ? | - |
? | |
| NADP+ | - |
Homo sapiens | 2'-phospho-cyclic ADP-ribose + nicotinamide | - |
? | |
| NADP+ | - |
Aplysia californica | 2'-phospho-cyclic ADP-ribose + nicotinamide | - |
? | |
| NGDP+ | enzyme cyclizes nicotinamide guanine dinucleotide to produce a fluorescent product, cyclic GDP-ribose, which has a site of cyclization different from cADPR | Homo sapiens | 2'-phospho-cyclic GDP-ribose + nicotinamide | - |
? | |
| NGDP+ | enzyme cyclizes nicotinamide guanine dinucleotide to produce a fluorescent product, cyclic GDP-ribose, which has a site of cyclization different from cADPR | Aplysia californica | 2'-phospho-cyclic GDP-ribose + nicotinamide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 2'-phospho-cyclic-ADP-ribose transferase | - |
Homo sapiens |
| 2'-phospho-cyclic-ADP-ribose transferase | - |
Aplysia californica |
| ADP-ribosyl cyclase 1 | - |
Homo sapiens |
| ADP-ribosyl cyclase 1 | - |
Aplysia californica |
| ADPRC 1 | - |
Homo sapiens |
| CD38 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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