Application | Comment | Organism |
---|---|---|
drug development | the hypoxanthineguanine phosphoribosyltransferase (HGPRT) represents a potential target for specific inhibitor development | Mycolicibacterium smegmatis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the antimicrobial activity of acyclic nucleoside phosphonates (ANP) prodrugs diethyl (2R,15S)-7-[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl]-2-benzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-10-(2-hydroxyethyl)-4,13-dioxo-15-(2-phenylethyl)-3,7,10,14-tetraaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate and diethyl (2R,15S)-2-benzyl-4,13-bis[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-10-(2-hydroxyethyl)-4,13-dioxo-7-[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl]-15-(2-phenylethyl)-3,7,10,14-tetraaza-4lambda5,13lambda5-diphosphahexadecane-1,16-dioate is not attributable to inhibition of HGPRT | Mycolicibacterium smegmatis | |
[2-([2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][2-[(2-hydroxyethyl)(2-phosphonoethyl)amino]ethyl]amino)ethyl]phosphonic acid | - |
Mycolicibacterium smegmatis | |
[2-[(2-hydroxyethyl)(2-[[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-phosphonoethyl)amino]ethyl)amino]ethyl]phosphonic acid | - |
Mycolicibacterium smegmatis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate | Mycolicibacterium smegmatis | - |
GMP + diphosphate | - |
? | |
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate | Mycolicibacterium smegmatis ATCC 700084 | - |
GMP + diphosphate | - |
? | |
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate | Mycolicibacterium smegmatis mc(2)155 | - |
GMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | Mycolicibacterium smegmatis | - |
IMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | Mycolicibacterium smegmatis ATCC 700084 | - |
IMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | Mycolicibacterium smegmatis mc(2)155 | - |
IMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycolicibacterium smegmatis | A0R593 | - |
- |
Mycolicibacterium smegmatis ATCC 700084 | A0R593 | - |
- |
Mycolicibacterium smegmatis mc(2)155 | A0R593 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycolicibacterium smegmatis | GMP + diphosphate | - |
? | |
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycolicibacterium smegmatis ATCC 700084 | GMP + diphosphate | - |
? | |
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycolicibacterium smegmatis mc(2)155 | GMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycolicibacterium smegmatis | IMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycolicibacterium smegmatis ATCC 700084 | IMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycolicibacterium smegmatis mc(2)155 | IMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HGPRT | - |
Mycolicibacterium smegmatis |
HPT | - |
Mycolicibacterium smegmatis |
hypoxanthine-guanine phosphoribosyltransferase | - |
Mycolicibacterium smegmatis |
MSMEG_6110 | locus name | Mycolicibacterium smegmatis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mycolicibacterium smegmatis |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of the HGPRT gene (DELTAhgprt) in the model organism Mycobacterium smegmatis confirms that this enzyme is not essential for Mycobacterium smegmatis' growth | Mycolicibacterium smegmatis |
physiological function | hypoxanthine-guanine phosphoribosyltransferase (HGPRT) catalyzes the formation of guanosine-5'-monophosphate from guanine and inosine-5'-monophosphate from hypoxanthine. It is the key enzyme in the purine salvage pathway, catalyzes the synthesis of inosine- or guanosine-5'-monophosphate via replacement of the 1-diphosphate group in phosphoribosyl diphosphate with a corresponding free nucleobase. Deletion of the HGPRT gene (DELTAhgprt) in the model organism Mycobacterium smegmatis confirms that this enzyme is not essential for Mycobacterium smegmatis' growth | Mycolicibacterium smegmatis |