Activating Compound | Comment | Organism | Structure |
---|---|---|---|
IMP | - |
Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
9-deazaguanine | uncompetitive inhibitor | Plasmodium falciparum | |
GMP | competitive inhibitor with respect to guanine, xanthine, and 5-phospho-alpha-D-ribose 1-diphosphate | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0016 | - |
IMP | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.0039 | - |
diphosphate | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.0042 | - |
diphosphate | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.007 | - |
IMP | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.053 | - |
5-phospho-alpha-D-ribose 1-diphosphate | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.078 | - |
xanthine | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.101 | - |
xanthine | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
1.08 | - |
5-phospho-alpha-D-ribose 1-diphosphate | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | dependent on | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GMP + diphosphate | Plasmodium falciparum | - |
guanine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
IMP + diphosphate | Plasmodium falciparum | - |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
XMP + diphosphate | Plasmodium falciparum | - |
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | P20035 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GMP + diphosphate | - |
Plasmodium falciparum | guanine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
IMP + diphosphate | - |
Plasmodium falciparum | hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Plasmodium falciparum | XMP + diphosphate | - |
r | |
XMP + diphosphate | - |
Plasmodium falciparum | xanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
HGXPRT | - |
Plasmodium falciparum |
hypoxanthine-guanine-xanthine phosphoribosyltransferase | - |
Plasmodium falciparum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0036 | - |
IMP | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.0042 | - |
IMP | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.2 | - |
5-phospho-alpha-D-ribose 1-diphosphate | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.2 | - |
xanthine | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
1.6 | - |
5-phospho-alpha-D-ribose 1-diphosphate | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
1.6 | - |
xanthine | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.18 | - |
5-phospho-alpha-D-ribose 1-diphosphate | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.6 | - |
IMP | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
0.9 | - |
diphosphate | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
1 | - |
diphosphate | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
2.2 | - |
IMP | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
2.6 | - |
xanthine | unactivated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
16 | - |
xanthine | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum | |
30 | - |
5-phospho-alpha-D-ribose 1-diphosphate | IMP-activated enzyme, at pH 7.4 and 23°C | Plasmodium falciparum |