Literature summary for 2.4.2.8 extracted from

Mastrangelo, L.; Kim, J.E.; Miyanohara, A.; Kang, T.H.; Friedmann, T.
Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase (2012), Proc. Natl. Acad. Sci. USA, 109, 3377-3382.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00492	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
HGPRT	-	Homo sapiens
HPRT	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	production of enzyme-deficient human Coxsackievirus-induced pluripotent stem cells and human HUES11 embryonic stem cells using shRNA. Both cells show >99% enzyme knock-down and demonstrate markedly decreased expression of the purinergic P2Y1 receptor mRNA. In Coxsackievirus-induced cells, P2Y1 mRNA and protein down-regulation by hypoxanthine phosphoribosyltransferase knockdown is refractory to activation by the P2Y1 receptor agonist ATP and shows aberrant purinergic signaling, as reflected by marked deficiency of the transcription factor pCREB and constitutive activation of the MAP kinases phospho-ERK1/2. Moreover, hypoxanthine phosphoribosyltransferase-knockdown Coxsackievirus-induced cells also demonstrate marked reduction of phosphorylated beta-catenin	Homo sapiens

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Release 2023.1 (January 2023)