Application | Comment | Organism |
---|---|---|
medicine | potential target for antiparasitic chemotherapy | Schistosoma mansoni |
Cloned (Comment) | Organism |
---|---|
DNA sequence determination, expression in Escherichia coli | Schistosoma mansoni |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0021 | - |
guanine | native enzyme | Schistosoma mansoni | |
0.0027 | - |
guanine | native enzyme | Schistosoma mansoni | |
0.0037 | - |
hypoxanthine | native enzyme | Schistosoma mansoni | |
0.0042 | - |
hypoxanthine | recombinant enzyme | Schistosoma mansoni |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Schistosoma mansoni |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26000 | - |
x * 26000, SDS-PAGE | Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Schistosoma mansoni |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
kinetics | Schistosoma mansoni |
5.4 | - |
purified enzyme, substrate hypoxanthine | Schistosoma mansoni |
5.9 | - |
recombinant enzyme, substrate hypoxanthine | Schistosoma mansoni |
7.6 | - |
purified enzyme, substrate guanine | Schistosoma mansoni |
8.1 | - |
recombinant enzyme, substrate guanine | Schistosoma mansoni |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Schistosoma mansoni | GMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Schistosoma mansoni | IMP + diphosphate | - |
? | |
additional information | kinetic study | Schistosoma mansoni | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 26000, SDS-PAGE | Schistosoma mansoni |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Schistosoma mansoni |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.4 | - |
hypoxanthine | native enzyme | Schistosoma mansoni | |
2.6 | - |
hypoxanthine | recombinant enzyme | Schistosoma mansoni | |
4.3 | - |
guanine | native enzyme | Schistosoma mansoni | |
5 | - |
guanine | recombinant enzyme | Schistosoma mansoni |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Schistosoma mansoni |