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Literature summary for 2.4.2.8 extracted from

  • Hochstadt, J.
    Hypoxanthine phosphoribosyltransferase and guanine phosphoribosyltransferase from enteric bacteria (1978), Methods Enzymol., 51, 549-558.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
acetate slightly activating Salmonella enterica subsp. enterica serovar Typhimurium
acetate slightly activating Escherichia coli

General Stability

General Stability Organism
5-phospho-alpha-D-ribose 1-diphosphate stabilizes Salmonella enterica subsp. enterica serovar Typhimurium
5-phospho-alpha-D-ribose 1-diphosphate stabilizes Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
6-aminopurine nucleotides
-
Escherichia coli
6-aminopurine nucleotides
-
Salmonella enterica subsp. enterica serovar Typhimurium
6-Hydroxypurine nucleotides
-
Escherichia coli
6-Hydroxypurine nucleotides
-
Salmonella enterica subsp. enterica serovar Typhimurium
Ba2+ strong Escherichia coli
Ba2+ strong Salmonella enterica subsp. enterica serovar Typhimurium
Ca2+ strong Escherichia coli
Ca2+ strong Salmonella enterica subsp. enterica serovar Typhimurium
nucleotides all free 5'-nucleotides are inhibitory, 6-OH purine nucleotides are most inhibitory, while 6-NH2 purine only at high concentrations Escherichia coli
nucleotides all free 5'-nucleotides are inhibitory, 6-OH purine nucleotides are most inhibitory, while 6-NH2 purine only at high concentrations Salmonella enterica subsp. enterica serovar Typhimurium
ppGpp strong Escherichia coli
ppGpp strong Salmonella enterica subsp. enterica serovar Typhimurium
Zn2+ strong Escherichia coli
Zn2+ strong Salmonella enterica subsp. enterica serovar Typhimurium

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Salmonella enterica subsp. enterica serovar Typhimurium 16020
-
membrane
-
Escherichia coli 16020
-
periplasm
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
periplasm
-
Escherichia coli
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement for Mg2+ or Mn2+ Salmonella enterica subsp. enterica serovar Typhimurium
Mg2+ absolute requirement for Mg2+ or Mn2+ Escherichia coli
Mn2+ absolute requirement for Mg2+ or Mn2+ Salmonella enterica subsp. enterica serovar Typhimurium
Mn2+ absolute requirement for Mg2+ or Mn2+ Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli
-
phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
strain LT-2
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes
-

Purification (Commentary)

Purification (Comment) Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
additional information
-
-
Escherichia coli

Storage Stability

Storage Stability Organism
-20°C, dilute aqueous purified enzyme preparation, a few weeks Salmonella enterica subsp. enterica serovar Typhimurium
-20°C, dilute aqueous purified enzyme preparation, a few weeks Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanine + 5-phospho-alpha-D-ribose 1-diphosphate phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes, and catalyse the 2 reactions with different specificities Salmonella enterica subsp. enterica serovar Typhimurium GMP + diphosphate
-
?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes, and catalyse the 2 reactions with different specificities Escherichia coli GMP + diphosphate
-
?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes, and catalyse the 2 reactions with different specificities Salmonella enterica subsp. enterica serovar Typhimurium IMP + diphosphate
-
?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes, and catalyse the 2 reactions with different specificities Escherichia coli IMP + diphosphate
-
?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium XMP + diphosphate
-
?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
Escherichia coli XMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
GPRT phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes Salmonella enterica subsp. enterica serovar Typhimurium
GPRT phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes Escherichia coli
HPRT phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes Salmonella enterica subsp. enterica serovar Typhimurium
HPRT phosphoribosyltransferases for hypoxanthine and guanine are separate enzymes Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
guanine phosphoribosyltransferase Salmonella enterica subsp. enterica serovar Typhimurium
7.9
-
guanine phosphoribosyltransferase Escherichia coli
8.4
-
hypoxanthine phosphoribosyltransferase Salmonella enterica subsp. enterica serovar Typhimurium
8.4
-
hypoxanthine phosphoribosyltransferase Escherichia coli
8.6
-
substrate xanthine Salmonella enterica subsp. enterica serovar Typhimurium
8.6
-
substrate xanthine Escherichia coli