Literature summary for 2.4.2.7 extracted from

Ceballos-Picot, I.; Mockel, L.; Potier, M.C.; Dauphinot, L.; Shirley, T.L.; Torero-Ibad, R.; Fuchs, J.; Jinnah, H.A.
Hypoxanthine-guanine phosphoribosyl transferase regulates early developmental programming of dopamine neurons: implications for Lesch-Nyhan disease pathogenesis (2009), Hum. Mol. Genet., 18, 2317-2327.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in MN-9D cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	APRT activity in HPRT-deficient MN9D mutant cells, overview	Homo sapiens
0.0073	-	wild-type MN9D cells	Homo sapiens

Synonyms

Synonyms	Comment	Organism
APRT	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	mutational HPRT deficiency leads to increased APRT expression and activity in MN9D cells, microarray analysis of HPRT-deficient MN9D cells, phenotype with increases in APRT and mRNAs for engrailed 1 and 2, En1 and En2, transcription factors, overview	additional information

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Release 2023.1 (January 2023)