Literature summary for 2.4.2.7 extracted from

Ambrozin, A.R.; Leite, A.C.; Silva, M.; Vieira, P.C.; Fernandes, J.B.; Thiemann, O.H.; da Silva, M.F.; Oliva, G.
Screening of Leishmania APRT enzyme inhibitors (2005), Pharmazie, 60, 781-784.

Search for more literature for 2.4.2.7

Application

Application	Comment	Organism
drug development	the enzyme is a target for antileishmanicidal drug development	Leishmania tarentolae

Inhibitors

Inhibitors	Comment	Organism	Structure
isodutaduprine	alkaloid from Almeidea rubra, 21.6% inhibition at 0.0356 mM of the recombinant enzyme	Leishmania tarentolae
isokokusagine	alkaloid from Almeidea rubra, 44.6% inhibition at 0.0412 mM of the recombinant enzyme	Leishmania tarentolae
isoskimmianine	alkaloid from Almeidea rubra, 39.1% inhibition at 0.0386 mM of the recombinant enzyme	Leishmania tarentolae
additional information	methanolic and hexanic extracts from roots and leaves of Cedrela fissilis and from fruits, branches and leaves of Cipadessa fruticosa show strong antileishmanicidal activities, the inhibitory activities of plant organ extracts with dichloromethane are lower, overview	Leishmania tarentolae

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Leishmania tarentolae

Organism

Organism	UniProt	Comment	Textmining
Leishmania tarentolae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine	-	Leishmania tarentolae	AMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
APRT	-	Leishmania tarentolae

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Leishmania tarentolae

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Leishmania tarentolae

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Release 2023.1 (January 2023)