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Literature summary for 2.4.2.6 extracted from

  • Kaminski, P.A.; Labesse, G.
    Phosphodeoxyribosyltransferases: designed enzymes for deoxyribonucleotide synthesis (2013), J. Biol. Chem., 288, 6534-6541.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Lactobacillus leichmannii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
11
-
2'-deoxycytidine mutant F13R/D92S/N123S, pH 6.0, 37°C Lactobacillus leichmannii
22
-
2'-deoxycytidine mutant F13R/D92S, pH 6.0, 37°C Lactobacillus leichmannii

Organism

Organism UniProt Comment Textmining
Lactobacillus leichmannii Q9R5V5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxyadenosine + 5-fluorouracil reaction is catalyzed by mutants F13R/D92S/N123S and F13Q/D92S/N123S Lactobacillus leichmannii 2'-deoxy-D-ribosyl-5-fluorouracil + adenine
-
?
2'-deoxycytidine + 2,6-diaminopurine reaction is catalyzed by mutants F13R/D92S/N123S and F13Q/D92S/N123S Lactobacillus leichmannii 2,6-diaminopurine 2-deoxy-D-riboside + cytosine
-
?
2'-deoxycytidine + 5-bromouracil reaction is catalyzed by mutants F13R/D92S/N123S and F13Q/D92S/N123S Lactobacillus leichmannii 2'-deoxy-5-bromouridine + cytosine
-
?
2'-deoxycytidine + 6-chloropurine reaction is catalyzed by mutants F13R/D92S/N123S and F13Q/D92S/N123S Lactobacillus leichmannii 6-chloropurine 2-deoxy-D-ribose 5-phosphate + cytosine
-
?
2'-deoxycytidine + adenine
-
Lactobacillus leichmannii 2'-deoxyadenosine + cytosine
-
?
dCMP + 2,6-dichloropurine reaction is catalyzed by mutants F13R/D92S/N123S and F13Q/D92S/N123S Lactobacillus leichmannii 2,6-dichloropurin-9-yl-2'-deoxy-beta-D-ribose 5'-phosphate + cytosine
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.3
-
2'-deoxycytidine mutant F13R/D92S, pH 6.0, 37°C Lactobacillus leichmannii
2.1
-
2'-deoxycytidine mutant F13R/D92S/N123S, pH 6.0, 37°C Lactobacillus leichmannii

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.0136
-
2'-deoxycytidine mutant F13R/D92S, pH 6.0, 37°C Lactobacillus leichmannii
0.192
-
2'-deoxycytidine mutant F13R/D92S/N123S, pH 6.0, 37°C Lactobacillus leichmannii