Protein Variants | Comment | Organism |
---|---|---|
F176L | the mutation is associated with ethambutol resistance | Mycobacterium tuberculosis |
K174T | the mutation is associated with ethambutol resistance | Mycobacterium tuberculosis |
W175C | the mutation is associated with ethambutol resistance | Mycobacterium tuberculosis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mycobacterium tuberculosis | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis | - |
trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate | - |
? | |
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis H37Rv | - |
trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WFR5 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WFR5 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycobacterium tuberculosis | trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate | - |
? | |
trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycobacterium tuberculosis H37Rv | trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DPPR synthase | - |
Mycobacterium tuberculosis |
Rv3806c | - |
Mycobacterium tuberculosis |
ubiA | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of the wild type enzyme leads to increased resistance to ethambutol in Mycobaterium tuberculosis | Mycobacterium tuberculosis |