Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[(5-(3-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid | - |
Escherichia coli | |
2-[(5-(3-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]propanoic acid | - |
Escherichia coli | |
2-[(5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid | the angiogenic response of 4d is estimated using the chick chorionic allantoic membrane (CAM) assay | Escherichia coli | |
2-[(5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]propanoic acid | - |
Escherichia coli | |
2-[(5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid | - |
Escherichia coli | |
2-[(5-(4-nitrophenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid | - |
Escherichia coli | |
4,5-diphenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione | - |
Escherichia coli | |
5-(3-chlorophenyl)-4H-1,2,4-triazole-3-thiol | - |
Escherichia coli | |
5-(3-pyridyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione | - |
Escherichia coli | |
5-(4-chlorophenyl)-4H-1,2,4-triazole-3-thiol | - |
Escherichia coli | |
5-(4-pyridyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione | binding mode, modeling | Escherichia coli | |
7-deazaxanthine | - |
Escherichia coli | |
KIN59 | - |
Escherichia coli | |
additional information | synthesis of 1,2,4-triazoles as thymidine phosphorylase inhibitors and possible future anti-tumor drugs for treatment of human disease. Molecular docking study. Cytoxicity study. No inhibition by 5-(4-methylphenyl)-4H-1,2,4-triazole-3-thiol, 5-(4-nitrophenyl)- 4H-1,2,4-triazole-3-thiol, 5-(4-methylphenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione, 5-(3,4,5-trimethoxyphenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione, 5-(3-chlorophenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione, 5-(4-chlorophenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione, and 2-[(5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetic acid | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | Escherichia coli | - |
thymidine + phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0C037 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Escherichia coli | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
Escherichia coli | thymidine + phosphate | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.03868 | - |
pH 7.4, 25°C | Escherichia coli | 7-deazaxanthine | |
0.0439 | - |
pH 7.4, 25°C | Escherichia coli | 2-[(5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid | |
0.062 | - |
pH 7.4, 25°C | Escherichia coli | 5-(3-chlorophenyl)-4H-1,2,4-triazole-3-thiol | |
0.0645 | - |
pH 7.4, 25°C | Escherichia coli | 2-[(5-(4-nitrophenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid | |
0.0823 | - |
pH 7.4, 25°C | Escherichia coli | 5-(4-pyridyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione | |
0.0946 | - |
pH 7.4, 25°C | Escherichia coli | 2-[(5-(3-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]propanoic acid | |
0.1123 | - |
pH 7.4, 25°C | Escherichia coli | 5-(3-pyridyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione | |
0.1438 | - |
pH 7.4, 25°C | Escherichia coli | 2-[(5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid | |
0.1634 | - |
pH 7.4, 25°C | Escherichia coli | 2-[(5-(3-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid | |
0.1876 | - |
pH 7.4, 25°C | Escherichia coli | 5-(4-chlorophenyl)-4H-1,2,4-triazole-3-thiol | |
0.2206 | - |
pH 7.4, 25°C | Escherichia coli | 2-[(5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]propanoic acid | |
0.2734 | - |
pH 7.4, 25°C | Escherichia coli | 4,5-diphenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione |