Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2,5-difluorobenzyl)-N-(2-fluorophenyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(2-methoxyphenyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(3-fluorophenyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(3-methoxyphenyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(3-nitrophenyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(4-(trifluoromethyl)phenyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(4-fluorophenyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(4-methoxyphenyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(4-nitrophenyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(m-tolyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(o-tolyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
4-(2,5-difluorobenzyl)-N-(p-tolyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
7-deazaxanthine | - |
Escherichia coli | |
additional information | synthesis and molecular docking study of piperazine derivatives as potent inhibitor of thymidine phosphorylase, overview | Escherichia coli | |
N-(2-bromophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
N-(2-chlorophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
N-(3,4-dichlorophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
N-(3-bromophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
N-(4-bromophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | - |
Escherichia coli | |
N-(adamantan-1-yl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | Escherichia coli | - |
thymidine + phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0C037 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Escherichia coli | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
Escherichia coli | thymidine + phosphate | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0011 | - |
pH 7.4, 25°C | Escherichia coli | N-(2-chlorophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | |
0.0012 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(3-fluorophenyl)piperazine-1-carbothioamide | |
0.0016 | - |
pH 7.4, 25°C | Escherichia coli | N-(3,4-dichlorophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | |
0.002 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(4-(trifluoromethyl)phenyl)piperazine-1-carbothioamide | |
0.0025 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(2-methoxyphenyl)piperazine-1-carbothioamide | |
0.003 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(2-fluorophenyl)piperazine-1-carbothioamide | |
0.0081 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(4-nitrophenyl)piperazine-1-carbothioamide | |
0.0116 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(4-methoxyphenyl)piperazine-1-carbothioamide | |
0.0122 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(3-methoxyphenyl)piperazine-1-carbothioamide | |
0.0143 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(o-tolyl)piperazine-1-carbothioamide | |
0.0146 | - |
pH 7.4, 25°C | Escherichia coli | N-(3-bromophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | |
0.0173 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(p-tolyl)piperazine-1-carbothioamide | |
0.0191 | - |
pH 7.4, 25°C | Escherichia coli | N-(2-bromophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | |
0.0223 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(m-tolyl)piperazine-1-carbothioamide | |
0.0246 | - |
pH 7.4, 25°C | Escherichia coli | N-(4-bromophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | |
0.0323 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(3-nitrophenyl)piperazine-1-carbothioamide | |
0.03868 | - |
pH 7.4, 25°C | Escherichia coli | 7-deazaxanthine | |
0.0422 | - |
pH 7.4, 25°C | Escherichia coli | N-(adamantan-1-yl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide | |
0.6 | - |
pH 7.4, 25°C | Escherichia coli | 4-(2,5-difluorobenzyl)-N-(4-fluorophenyl)piperazine-1-carbothioamide |