Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
KKU-M139 cell | cholangiocarcinoma-derived cell line, which has a naturally high level of endogenous thymidine phosphorylase | Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | transient decrease of mRNA and protein expression by 87.1% and 72.5%, respectively, using siRNAleads to significant decrease in migration of KKU-M139 cells, and suppresses migration and tube formation of human umbilical vein endothelial cells. siRNA also reduces the ability of thymidine phosphorylase to resist hypoxia-induced apoptosis, while suppression of thymidine phosphorylase reduces the sensitivity of KKU-M139 cells to 5-fluorouracil | Homo sapiens |