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Literature summary for 2.4.2.4 extracted from

  • Thanasai, J.; Limpaiboon, T.; Jearanaikoon, P.; Sripa, B.; Pairojkul, C.; Tantimavanich, S.; Miwa, M.
    Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma (2010), World J. Gastroenterol., 16, 1631-1638.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
KKU-M139 cell cholangiocarcinoma-derived cell line, which has a naturally high level of endogenous thymidine phosphorylase Homo sapiens
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General Information

General Information Comment Organism
physiological function transient decrease of mRNA and protein expression by 87.1% and 72.5%, respectively, using siRNAleads to significant decrease in migration of KKU-M139 cells, and suppresses migration and tube formation of human umbilical vein endothelial cells. siRNA also reduces the ability of thymidine phosphorylase to resist hypoxia-induced apoptosis, while suppression of thymidine phosphorylase reduces the sensitivity of KKU-M139 cells to 5-fluorouracil Homo sapiens