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Literature summary for 2.4.2.4 extracted from

  • Marak, D.; Otmar, M.; Votruba, I.; Dracinsky, M.; Krecmerova, M.
    8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase (2011), Bioorg. Med. Chem. Lett., 21, 652-654.
    View publication on PubMed
Search for more literature for 2.4.2.4

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
[8-(2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-1-yl)octyl]phosphonic acid
-
 Escherichia coli
[8-(2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-1-yl)octyl]phosphonic acid no antitumor activity found with CCRF-CEM T-lymphoblastoid cells, human promyelocytic leukemia HL-60 cells, human cervix carcinoma HeLa S3 cells Homo sapiens
[8-(2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-1-yl)octyl]phosphonic acid
-
 Escherichia coli
[8-(2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-1-yl)octyl]phosphonic acid no antitumor activity found with CCRF-CEM T-lymphoblastoid cells, human promyelocytic leukemia HL-60 cells, human cervix carcinoma HeLa S3 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Escherichia coli
-
commercial preparation
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0017
-
 enzyme purified from placenta, pH not specified in the publication, temperature not specified in the publication Homo sapiens [8-(2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-1-yl)octyl]phosphonic acid
0.0068
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli [8-(2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-1-yl)octyl]phosphonic acid
0.0073
-
 recombinant enzyme, pH not specified in the publication, temperature not specified in the publication Homo sapiens [8-(2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-1-yl)octyl]phosphonic acid
0.0114
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli [8-(2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-1-yl)octyl]phosphonic acid
0.0151
-
 enzyme purified from placenta, pH not specified in the publication, temperature not specified in the publication Homo sapiens [8-(2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-1-yl)octyl]phosphonic acid
0.027
-
 recombinant enzyme, pH not specified in the publication, temperature not specified in the publication Homo sapiens [8-(2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-1-yl)octyl]phosphonic acid