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Literature summary for 2.4.2.4 extracted from

  • Pomeisl, K.; Holy, A.; Votruba, I.
    Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase (2008), Nucleic Acids Symp. Ser., 52, 657-658.
    View publication on PubMed
Search for more literature for 2.4.2.4

Cloned(Commentary)

Cloned (Comment) Organism
expressed in V-79 hamster cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(R)-(1-fluoro-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propan-2-yloxy)methylphosphonic phosphoric anhydride strong inhibitory effect Homo sapiens
(R)-1-[3-fluoro-2-(phosphonomethoxy)propyl]thymine efficient inhibitor Homo sapiens
(S)-(1-fluoro-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propan-2-yloxy)methylphosphonic phosphoric anhydride strong inhibitory effect Homo sapiens
(S)-1-[3-fluoro-2-(phosphonomethoxy)propyl]thymine efficient inhibitor Homo sapiens
([(1R)-2-fluoro-1-[(5-methyl-2,6-dioxotetrahydropyrimidin-1(2H)-yl)methyl]ethoxy]methyl)phosphonic acid low inhibitory effect Homo sapiens
([(1S)-2-fluoro-1-[(5-methyl-2,6-dioxotetrahydropyrimidin-1(2H)-yl)methyl]ethoxy]methyl)phosphonic acid low inhibitory effect Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphoma cell SD Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
uridine + phosphate
-
 Homo sapiens uracil + D-ribose 1-phosphate
-
 ?