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Literature summary for 2.4.2.4 extracted from

  • Allan, A.L.; Gladstone, P.L.; Price, M.L.; Hopkins, S.A.; Juarez, J.C.; Donate, F.; Ternansky, R.J.; Shaw, D.E.; Ganem, B.; Li, Y.; Wang, W.; Ealick, S.
    Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase (2006), J. Med. Chem., 49, 7807-7815.
    View publication on PubMed
Search for more literature for 2.4.2.4

Inhibitors

Inhibitors Comment Organism Structure
(4xi)-2',3'-O-[(1R)-2-carboxyethylidene]-5-methylcytidine
-
 Homo sapiens
(4xi)-5-methyl-2',3'-O-[(1R)-2-phosphonoethylidene]cytidine
-
 Homo sapiens
[[(2R,3aR,6aR)-6-(4-amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-(hydroxymethyl)hexahydrofuro[3,4-b]furan-2-yl]methyl]phosphonic acid
-
 Homo sapiens
[[(2S,3aR,6aR)-6-(4-amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-(hydroxymethyl)hexahydrofuro[3,4-b]furan-2-yl]methyl]phosphonic acid
-
 Homo sapiens
[[(2S,3aR,6aS)-4-(4-amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-6-(hydroxymethyl)hexahydrofuro[3,4-b]furan-2-yl]methyl]phosphonic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P19971
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000236
-
 (4xi)-5-methyl-2',3'-O-[(1R)-2-phosphonoethylidene]cytidine
-
 Homo sapiens
0.00105
-
 [[(2S,3aR,6aR)-6-(4-amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-(hydroxymethyl)hexahydrofuro[3,4-b]furan-2-yl]methyl]phosphonic acid
-
 Homo sapiens
0.00803
-
 [[(2S,3aR,6aS)-4-(4-amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-6-(hydroxymethyl)hexahydrofuro[3,4-b]furan-2-yl]methyl]phosphonic acid
-
 Homo sapiens
0.0334
-
 [[(2R,3aR,6aR)-6-(4-amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-(hydroxymethyl)hexahydrofuro[3,4-b]furan-2-yl]methyl]phosphonic acid
-
 Homo sapiens
0.0435
-
 (4xi)-2',3'-O-[(1R)-2-carboxyethylidene]-5-methylcytidine
-
 Homo sapiens