Literature summary for 2.4.2.4 extracted from

Veres, Z.; Neszmelyi, A.; Szabolcs, A.; Denes, G.
Inhibition of uridine phosphorylase by pyrimidine nucleoside analogs and consideration of substrate binding to the enzyme based on solution conformation as seen by NMR spectroscopy (1988), Eur. J. Biochem., 178, 173-181.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2',3'-Dideoxy-5-ethyluridine	9% inhibition at 10 mM	Rattus norvegicus
3'-Azido-2',3'-dideoxy-5-ethyluridine	16% inhibition at 10 mM	Rattus norvegicus
3'-Azido-2',3'-dideoxy-5-methyluridine	6% inhibition at 10 mM	Rattus norvegicus
3'-Bromo-2',3'-dideoxy-5-ethyluridine	9% inhibition at 5 mM	Rattus norvegicus
3'-Chloro-2',3'-dideoxy-5-ethyluridine	26% inhibition at 10 mM	Rattus norvegicus
3'-Chloro-2',3'-dideoxy-5-methyluridine	18% inhibition at 10 mM	Rattus norvegicus
Arabinofuranosyl-5-ethyluracil	10% inhibition at 10 mM	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestinal mucosa	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
thymidine + phosphate	-	Rattus norvegicus	thymine + 2-deoxy-D-ribose 1-phosphate	-	?

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Release 2023.1 (January 2023)