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Literature summary for 2.4.2.4 extracted from
- Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase (1981), Biochim. Biophys. Acta, 654, 211-218.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
2 * 60000, SDS-PAGE | Homo sapiens |
| 110000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thymidine + phosphate | Homo sapiens | intact platelets degrade thymidine but are not able to synthesize thymidine from thymine | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 10 | - |
- |
Homo sapiens |
| 604 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bromodeoxyuridine + phosphate | - |
Homo sapiens | bromouracil + 2-deoxy-D-ribose | - |
? | |
| deoxyuridine + phosphate | 1.2-1.4 times the rate of thymidine at pH 5.7 | Homo sapiens | uracil + 2-deoxy-D-ribose 1-phosphate | - |
? | |
| fluorodeoxyuridine + phosphate | - |
Homo sapiens | fluorouracil + 2-deoxy-D-ribose | - |
? | |
| iododeoxyuridine + phosphate | - |
Homo sapiens | iodouracil + 2-deoxy-D-ribose | - |
? | |
| additional information | purine deoxyribonucleosides are no substrates | Homo sapiens | ? | - |
? | |
| thymidine + arsenate | - |
Homo sapiens | ? | - |
? | |
| thymidine + phosphate | - |
Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
ir | |
| thymidine + phosphate | intact platelets degrade thymidine but are not able to synthesize thymidine from thymine | Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 60000, SDS-PAGE | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 65 | - |
30 min, complete inactivation | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.7 | - |
- |
Homo sapiens |
| 7.5 | - |
- |
Homo sapiens |
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Release 2023.1 (January 2023)
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