Literature summary for 2.4.2.36 extracted from

Leppla, S.H.; Martin, O.C.; Muehl, L.A.
The exotoxin P. aeruginosa: a proenzyme having an unusual mode of activation (1978), Biochem. Biophys. Res. Commun., 81, 532-538.

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Activating Compound

Activating Compound	Comment	Organism	Structure
2-mercaptoethanol	activation, together with SDS or guanidine hydrochloride	Pseudomonas aeruginosa
cysteine	activation, together with SDS or guanidine hydrochloride	Pseudomonas aeruginosa
dithiothreitol	enhances activity together with urea	Pseudomonas aeruginosa
guanidine hydrochloride	enhances activity together with dithiothreitol, cysteine, 2-mercaptoethanol or sulfite	Pseudomonas aeruginosa
additional information	exotoxin is synthesized in a catalytically inactive, proenzyme form, unfolding of the toxin molecule may cause activation	Pseudomonas aeruginosa
SDS	enhances activity together with dithiothreitol, cysteine, 2-mercaptoethanol or sulfite	Pseudomonas aeruginosa
sulfite	activation, together with SDS or guanidine hydrochloride	Pseudomonas aeruginosa
Urea	enhances activity together with dithiothreitol	Pseudomonas aeruginosa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	exotoxin A	Pseudomonas aeruginosa	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + elongation factor 2	Pseudomonas aeruginosa	NAD-glycohydrolase activity without acceptor substrate	nicotinamide + ADPribose-elongation factor 2	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
culture supernatant	-	Pseudomonas aeruginosa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + elongation factor 2	NAD-glycohydrolase activity without acceptor substrate	Pseudomonas aeruginosa	nicotinamide + ADPribose-elongation factor 2	-	?

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Release 2023.1 (January 2023)