Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Clostridium perfringens | 5829 | - |
cytosol | - |
Clostridium botulinum | 5829 | - |
cytosol | - |
Clostridioides difficile | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
47000 | - |
x * 47000, SDS-PAGE | Clostridium perfringens |
49000 | - |
x * 49000, SDS-PAGE | Clostridium botulinum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [actin]-L-arginine177 | Clostridium perfringens | - |
nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+ | - |
? | |
NAD+ + [actin]-L-arginine177 | Clostridium botulinum | - |
nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+ | - |
? | |
NAD+ + [actin]-L-arginine177 | Clostridioides difficile | - |
nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridioides difficile | - |
- |
- |
Clostridium botulinum | - |
- |
- |
Clostridium perfringens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Clostridium perfringens |
- |
Clostridium botulinum |
- |
Clostridioides difficile |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | a large isoform of cyclophilin A, the multi-domain enzyme cyclophilin 40 (Cyp40), binds to the enzyme | Clostridium perfringens | additional information | - |
? | |
additional information | a large isoform of cyclophilin A, the multi-domain enzyme cyclophilin 40 (Cyp40), binds to the enzyme | Clostridioides difficile | additional information | - |
? | |
additional information | a large isoform of cyclophilin A, the multi-domain enzyme cyclophilin 40, binds to the enzyme | Clostridium botulinum | additional information | - |
? | |
NAD+ + [actin]-L-arginine177 | - |
Clostridium perfringens | nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+ | - |
? | |
NAD+ + [actin]-L-arginine177 | - |
Clostridium botulinum | nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+ | - |
? | |
NAD+ + [actin]-L-arginine177 | - |
Clostridioides difficile | nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 47000, SDS-PAGE | Clostridium perfringens |
? | x * 49000, SDS-PAGE | Clostridium botulinum |
Synonyms | Comment | Organism |
---|---|---|
C2 toxin | - |
Clostridium botulinum |
C2I | - |
Clostridium botulinum |
CDT | - |
Clostridioides difficile |
iota toxin | - |
Clostridium perfringens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme ADP-ribosylates G-actin in the cytosol of target cells resulting in depolymerization of F-actin, cell rounding and cell death | Clostridium perfringens |
physiological function | the enzyme ADP-ribosylates G-actin in the cytosol of target cells resulting in depolymerization of F-actin, cell rounding and cell death | Clostridium botulinum |
physiological function | the enzyme ADP-ribosylates G-actin in the cytosol of target cells resulting in depolymerization of F-actin, cell rounding and cell death | Clostridioides difficile |