Activating Compound | Comment | Organism | Structure |
---|---|---|---|
3-amino-1-methyl-5H-pyrido[4,3-b]indole | i.e. Trp-P-2, 71% activation at 3 mM | Meleagris sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole | i.e. Trp-P-1, 53% inhibition at 5 mM, IC50: 2.8 mM | Meleagris sp. | |
additional information | comparison of the effects of heterocyclic amines acting as potent carcinogens on poly(ADP-ribose) polymerase-1, PARP-1, EC 2.4.2.30, and the arginine-specific mono-ADP-ribosyltransferase A, overview | Meleagris sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Meleagris sp. | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Meleagris sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H2B + NAD+ | - |
Meleagris sp. | Nomega-[(2'-phospho-ADP)-D-ribosyl]-histone H2B-L-arginine + nicotinamide | - |
? | |
additional information | the enzyme is involved in signal transduction and cytoskeletal realignment | Meleagris sp. | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
arginine-specific mono-ADP-ribosyltransferase A | - |
Meleagris sp. |
MART-A | - |
Meleagris sp. |
mono-ADP-ribosyltransferase A | - |
Meleagris sp. |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Meleagris sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Meleagris sp. |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
2.8 | - |
i.e. Trp-P-1, 53% inhibition at 5 mM, IC50: 2.8 mM | Meleagris sp. | 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole |