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Literature summary for 2.4.2.31 extracted from

  • Paone, G.; Stevens, L.A.; Levine, R.L.; Bourgeois, C.; Steagall, W.K.; Gochuico, B.R.; Moss, J.
    ADP-ribosyltransferase-specific modification of human neutrophil peptide-1 (2006), J. Biol. Chem., 281, 17054-17060.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of isozymes ART1, ART3, ART4, ART5, ART2.2 in Escherichia coli, isozyme ART1synthesized in Escherichia coli, glycosylphosphatidylinositol-anchored ART1 released with phosphatidylinositol-specific phospholipase C from transfected NMU cells, or ART1 expressed endogenously on C2C12 myotubes modifiy arginine 14 on HNP-1 with a secondary site on arginine 24 Homo sapiens
expression of isozymes ART1, ART5, ART2.2 in Escherichia coli, ART1 expressed endogenously on C2C12 myotubes modifies arginine 14 on HNP-1 with a secondary site on arginine 24 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
human neutrophil peptide-1 substrate inhibition of isozymes ART1 and ART5 Homo sapiens
human neutrophil peptide-1 substrate inhibition of isozyme ART5 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface on epithelial cells lining human airways and cells, isozyme ART1 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
human neutrophil peptide-1 + NAD+ Homo sapiens human neutrophil peptide-1, HNP-1, from neutrophil cell surface, ADP-ribosylation of HNP-1 is primarily an activity of ART1 and occurs in inflammatory conditions and disease, lack of modified HNP-1 due to enzyme deficiency in the sputum leads to cystic fibrosis Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes ART1, ART3, ART4, and ART5
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Mus musculus
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isozymes ART1, ART2.2, and ART5
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell epithelial cells lining human airways and cells, isozyme ART1, bronchoalveolar lavage fluid Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human neutrophil peptide-1 + NAD+ human neutrophil peptide-1, HNP-1, from neutrophil cell surface, ADP-ribosylation of HNP-1 is primarily an activity of ART1 and occurs in inflammatory conditions and disease, lack of modified HNP-1 due to enzyme deficiency in the sputum leads to cystic fibrosis Homo sapiens Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
-
?
human neutrophil peptide-1 + NAD+ human neutrophil peptide-1, HNP-1, from neutrophil cell surface, isozyme ART1 is active on Arg14 and Arg24 Mus musculus Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
-
?
human neutrophil peptide-1 + NAD+ human neutrophil peptide-1, HNP-1, from neutrophil cell surface, isozyme ART1 shows high activity on Arg14 and Arg24, while isozymes ART3, ART4, ART5 are less or not active Homo sapiens Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
-
?
additional information substrate specificity, beta-defensin-1 is a poor substrate, overview Homo sapiens ?
-
?
additional information substrate specificity, human neutrophil peptide-1 is a poor substrate of isozymes ART2.2 and ART5, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
ADP-ribosyltransferase
-
Mus musculus
ADP-ribosyltransferase
-
Homo sapiens
arginine-specific ADP-ribosyltransferase
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Mus musculus
arginine-specific ADP-ribosyltransferase
-
Homo sapiens
ART
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Mus musculus
ART
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus
7.5
-
assay at Homo sapiens