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Literature summary for 2.4.2.31 extracted from

  • Krebs, C.; Adriouch, S.; Braasch, F.; Koestner, W.; Leiter, E.H.; Seman, M.; Lund, F.E.; Oppenheimer, N.; Haag, F.; Koch-Nolte, F.
    CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins (2005), J. Immunol., 174, 3298-3305.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information depletion of CD38 cells results in enhanced levels of cell surface etheno-ADP-ribosylation on CD38 T cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CD38 CD38, a potent ecto-NAD-glycohydrolase, controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins, CD38 decreases ART2-catalyzed ADP-ribosylation in trans by reducing the amount of ART substrate NAD+ Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface ART2 is attached to the cell surface by a glycosylphosphatidylinositol anchor in T-cells Mus musculus 9986
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membrane
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Mus musculus 16020
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Organism

Organism UniProt Comment Textmining
Mus musculus
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BALB/c and C57BL/6 mice, isozyme ART2
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Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte splenic lymphocyte subpopulations, ART2 is a T-cell-specific transferase, expression of CD38 and ART2 is inversely correlated on murine lymphocytes Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CD38, a potent ecto-NAD-glycohydrolase, controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins, overview, the enzyme is a a GPI-anchored, toxin-related ADP-ribosylating ectoenzyme, ART2 can sense and translate the local concentration of ecto-NAD into corresponding levels of ADP-ribosylated cell surface proteins, whereas CD38 controls the level of cell surface protein ADP-ribosylation by limiting the substrate availability for ART2 Mus musculus ?
-
?
P2X7 purinoceptor protein + NAD+ isozyme ART2 Mus musculus Nomega-[(2'-phospho-ADP)-D-ribosyl]-P2X7 purinoceptor protein-L-arginine + nicotinamide
-
?

Synonyms

Synonyms Comment Organism
ADP-ribosyltransferase-2
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Mus musculus
ART2
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Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus