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Literature summary for 2.4.2.30 extracted from

  • Banasik, M.; Stedeford, T.; Strosznajder, R.P.; Hsu, C.H.; Tanaka, S.; Ueda, K.
    Differential effects of heterocyclic amines on poly(ADP-ribose) polymerase-1 and mono-ADP-ribosyltransferase A (2006), J. Physiol. Pharmacol., 57 Suppl 4, 15-22.
    View publication on PubMed
Search for more literature for 2.4.2.30

Activating Compound

Activating Compound Comment Organism Structure
3-amino-1-methyl-5H-pyrido[4,3-b]indole i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole i.e. Trp-P-1, 94% inhibition at 5 mM, IC50: 0.22 mM Bos taurus
3-amino-1-methyl-5H-pyrido[4,3-b]indole i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM Bos taurus
additional information comparison of the effects of heterocyclic amines acting as potent carcinogens on PARP-1 and the arginine-specific mono-ADP-ribosyltransferase A, MART-A, EC 2.4.2.31, overview Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor Bos taurus the enzyme is a DNA repair enzyme nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor the enzyme is a DNA repair enzyme Bos taurus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + histone H2B
-
 Bos taurus nicotinamide + (ADP-D-ribosyl)-histone H2B
-
 ?

Synonyms

Synonyms Comment Organism
PARP-1
-
 Bos taurus
poly(ADP-ribose) polymerase-1
-
 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.22
-
 i.e. Trp-P-1, 94% inhibition at 5 mM, IC50: 0.22 mM Bos taurus 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole
2.2
-
 i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM Bos taurus 3-amino-1-methyl-5H-pyrido[4,3-b]indole