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Literature summary for 2.4.2.30 extracted from

  • Otto, H.; Reche, P.A.; Bazan, F.; Dittmar, K.; Haag, F.; Koch-Nolte, F.
    In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs) (2005), BMC Genomics, 6, 139.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.30

Cloned(Commentary)

Cloned (Comment) Organism
gene PARP, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Mus musculus
gene PARP1, chromosomal location 1q41-q42, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
gene PARP11, chromosomal location 12p13.3, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
gene PARP14, chromosomal location 3q21.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
gene PARP16, chromosomal location 15q22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
gene PARP2, chromosomal location 14q11.2-q12, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
gene PARP3, chromosomal location 3p21.1-22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
gene PARP4, chromosomal location 13q11, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
gene PARP6, chromosomal location 15q22.23, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
gene TNKS1, chromosomal location 8p23.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor Mus musculus
-
 nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor Homo sapiens
-
 nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O95271 TNKS1
-
Homo sapiens P09874 PARP-1
-
Homo sapiens Q2NL67 PARP-6
-
Homo sapiens Q460N5 PARP-14
-
Homo sapiens Q8N5Y8 PARP-16
-
Homo sapiens Q9NR21 PARP-11
-
Homo sapiens Q9UGN5 PARP-2
-
Homo sapiens Q9UKK3 PARP-4
-
Homo sapiens Q9Y6F1 PARP-3
-
Mus musculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains Mus musculus
a
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Mus musculus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Synonyms

Synonyms Comment Organism
B aggressive lymphoma protein 2
-
 Homo sapiens
More the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs Mus musculus
More the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs Homo sapiens
PARP
-
 Mus musculus
PARP
-
 Homo sapiens
TANK1
-
 Homo sapiens
tankyrase I
-
 Homo sapiens
TNKS-1
-
 Homo sapiens
TRF1-interacting ankyrin-related ADP-ribose polymerase
-
 Homo sapiens