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Literature summary for 2.4.2.30 extracted from

  • Chen, Y.; Schnetz, M.P.; Irarrazabal, C.E.; Shen, R.F.; Williams, C.K.; Burg, M.B.; Ferraris, J.D.
    Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1 (2007), Am. J. Physiol. Renal Physiol., 292, F981-F992.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information stable expression of the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP, clone KIAA0827/amino acids 1-547, in HEK-293 cells increases the expression of the enzyme Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of the enzyme in HEK-293 cells using a luciferase reporter vector, PARP-1 expression analysis, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information stable expression of the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP, amino acids 1-547, in HEK-293 cells increases the expression of the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-aminobenzamide
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PARP-1 inhibits the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP. Inhibition of TonEBP/OREBP transcriptional activity by PARP-1 does not require PARP-1 catalytic activity, functional interaction anaylsis, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PARP-1 inhibits the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP. Inhibition of TonEBP/OREBP transcriptional activity by PARP-1 does not require PARP-1 catalytic activity, functional interaction anaylsis, overview Homo sapiens ?
-
?
additional information the enzyme shows DNA-binding activity, and is physically associated with the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PARP-1
-
Homo sapiens
poly(ADP-ribose) polymerase-1
-
Homo sapiens