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Literature summary for 2.4.2.3 extracted from
- Uridine phosphorylase from Hymenolepis diminuta (Cestoda): kinetics and inhibition by pyrimidine nucleoside analogs (1996), Acta Biochim. Pol., 43, 733-741.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-(1',3'-dihydroxy-2'-propoxy)methyl-5-benzyluracil | i.e. DHPBU, competitive | Hymenolepis diminuta |  |
| 2,2'-Anhydro-5-ethyluridine | 0.001 mM, competitive | Hymenolepis diminuta | |
| 2,3'-anhydro-5-ethyluridine | competitive | Hymenolepis diminuta | |
| tetramethylene acyclouridine | - |
Hymenolepis diminuta | |
| uridine | - |
Hymenolepis diminuta | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.033 | - |
uridine | - |
Hymenolepis diminuta | |
| 0.05 | - |
ribose 1-phosphate | - |
Hymenolepis diminuta | |
| 0.204 | - |
Uracil | - |
Hymenolepis diminuta | |
| 0.806 | - |
phosphate | - |
Hymenolepis diminuta | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Hymenolepis diminuta | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Hymenolepis diminuta | - |
tapeworm | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Hymenolepis diminuta |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| uridine + phosphate = uracil + alpha-D-ribose 1-phosphate | sequential mechanism | Hymenolepis diminuta |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thymidine + phosphate | - |
Hymenolepis diminuta | thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? | |
| uridine + phosphate | - |
Hymenolepis diminuta | uracil + alpha-D-ribose 1-phosphate | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | - |
Hymenolepis diminuta |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00007 | - |
2,2'-Anhydro-5-ethyluridine | - |
Hymenolepis diminuta | |
| 0.00007 | - |
1-(1',3'-dihydroxy-2'-propoxy)methyl-5-benzyluracil | - |
Hymenolepis diminuta | |
| 0.0088 | - |
tetramethylene acyclouridine | - |
Hymenolepis diminuta | |
| 0.014 | - |
2,3'-anhydro-5-ethyluridine | - |
Hymenolepis diminuta | |
| 0.047 | - |
uridine | - |
Hymenolepis diminuta | |
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