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Literature summary for 2.4.2.3 extracted from

  • el Kouni, M.H.; el Kouni, M.M.; Naguib, F.N.
    Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines (1993), Cancer Res., 53, 3687-3693.
    View publication on PubMed
Search for more literature for 2.4.2.3

Inhibitors

Inhibitors Comment Organism Structure
Benzylacyclouridines 0.1 mM Homo sapiens
Benzylacyclouridines 0.1 mM Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Mus musculus
additional information
-
 additional information
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-deoxy-5-fluorouridine + phosphate 25% of the activity with uridine Mus musculus 5-fluorouracil + 5-deoxyribose-1-phosphate
-
 ?
5-fluoro-2'-deoxyuridine + phosphate 15% of the activity with uridine Mus musculus 5-fluorouracil + 2-deoxyribose-1-phosphate
-
 ?
5-fluorouridine + phosphate 15% of the activity with uridine Homo sapiens 5-fluorouracil + alpha-D-ribose-1-phosphate
-
 ?
5-fluorouridine + phosphate 85% of the activity with uridine Mus musculus 5-fluorouracil + alpha-D-ribose-1-phosphate
-
 ?
additional information
-
 Mus musculus ?
-
 ?
additional information no substrates are: thymidine, deoxyuridine, fluorodeoxyuridiune, 5'-deoxyfluorouridine Homo sapiens ?
-
 ?
uridine + phosphate liver enzyme is highly specific to uridine Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 ?
uridine + phosphate broader specificity than human enzyme Mus musculus uracil + alpha-D-ribose 1-phosphate
-
 ?