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Literature summary for 2.4.2.26 extracted from

  • de la Morena-Barrio, M.; Buil, A.; Anton, A.; Martinez-Martinez, I.; Minano, A.; Gutierrez-Gallego, R.; Navarro-Fernandez, J.; Aguila, S.; Souto, J.; Vicente, V.; Soria, J.; Corral, J.
    Identification of antithrombin-modulating genes. Role of LARGE, a gene encoding a bifunctional glycosyltransferase, in the secretion of proteins? (2013), PLoS ONE, 8, e64998.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293-EBNA cell
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 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
LARGE
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 Homo sapiens

General Information

General Information Comment Organism
malfunction LARGE gene silencing in Hep-G2 and HEK-EBNA cells does not affect SERPINC1 mRNA levels but significantly reduces the secretion of antithrombin with moderate intracellular retention Homo sapiens
physiological function LARGE is a modifier of plasma antithrombin Homo sapiens