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Literature summary for 2.4.2.22 extracted from

  • Jardim, A.; Bergeson, S.E.; Shih, S.; Carter, N.; Lucas, R.W.; Merlin, G.; Myler, P.J.; Stuart, K.; Ullman, B.
    Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis (1999), J. Biol. Chem., 274, 34403-34410.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme lacks a mammalian counterpart and is, therefore, a potential target for antiparasitic therapy Leishmania donovani

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Leishmania donovani

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0071
-
xanthine
-
Leishmania donovani
0.448
-
hypoxanthine
-
Leishmania donovani

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Leishmania donovani

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-phospho-alpha-D-ribose 1-diphosphate + guanine
-
Leishmania donovani GMP + diphosphate
-
?
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
-
Leishmania donovani IMP + diphosphate
-
?
5-phospho-alpha-D-ribose 1-diphosphate + xanthine
-
Leishmania donovani 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6
-
hypoxanthine
-
Leishmania donovani
3.5
-
xanthine
-
Leishmania donovani