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Literature summary for 2.4.2.2 extracted from

  • Gao, X.F.; Huang, X.R.; Sun, C.C.
    Role of each residue in catalysis in the active site of pyrimidine nucleoside phosphorylase from Bacillus subtilis: a hybrid QM/MM study (2006), J. Struct. Biol., 154, 20-26.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Bacillus subtilis P39142
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the function of His82, Arg169, and Lys188 is to stabilize the uridine in a high-energy conformation by means of electrostatic interactions. These residues are involved in catalysis. The function of Asp162 is likely to activate Lys188 for phosphorolytic catalysis through polarization effects Bacillus subtilis ?
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