Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoribosyl diphosphate + quinolinic acid | Homo sapiens | - |
nicotinate mononucleotide + diphosphate + CO2 | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15274 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
K-562 cell | - |
Homo sapiens | - |
leukemia cell | - |
Homo sapiens | - |
myeloid leukemia cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoribosyl diphosphate + quinolinic acid | - |
Homo sapiens | nicotinate mononucleotide + diphosphate + CO2 | - |
r |
Subunits | Comment | Organism |
---|---|---|
? | x * 35000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
QPRT | - |
Homo sapiens |
quinolinate phosphoribosyltransferase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | overexpression of Wilms' tumor gene 1 in hematopoietic progenitor cells and cell lines results in an increase of enzyme expression | up |
General Information | Comment | Organism |
---|---|---|
metabolism | key enzyme in the de novo nicotinamide adenine dinucleotide synthesis pathway | Homo sapiens |
physiological function | the enzyme with anti-apoptotic properties is a direct target gene of Wilms' tumor gene 1 in leukemic cells. Enzyme overexpression in K-562 leukemic cells increases resistance to imatinib | Homo sapiens |