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Literature summary for 2.4.2.19 extracted from

  • Ullmark, T.; Montano, G.; Jaervstrat, L.; Jernmark Nilsson, H.; Hakansson, E.; Drott, K.; Nilsson, B.; Vidovic, K.; Gullberg, U.
    Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms tumor gene 1 (WT1) protein in leukemic cells (2017), Biochem. Biophys. Res. Commun., 482, 802-807 .
    View publication on PubMed
Search for more literature for 2.4.2.19

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoribosyl diphosphate + quinolinic acid Homo sapiens
-
 nicotinate mononucleotide + diphosphate + CO2
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15274
-
-

Source Tissue

Source Tissue Comment Organism Textmining
K-562 cell
-
 Homo sapiens
-
leukemia cell
-
 Homo sapiens
-
myeloid leukemia cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoribosyl diphosphate + quinolinic acid
-
 Homo sapiens nicotinate mononucleotide + diphosphate + CO2
-
 r

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
QPRT
-
 Homo sapiens
quinolinate phosphoribosyltransferase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens overexpression of Wilms' tumor gene 1 in hematopoietic progenitor cells and cell lines results in an increase of enzyme expression up

General Information

General Information Comment Organism
metabolism key enzyme in the de novo nicotinamide adenine dinucleotide synthesis pathway Homo sapiens
physiological function the enzyme with anti-apoptotic properties is a direct target gene of Wilms' tumor gene 1 in leukemic cells. Enzyme overexpression in K-562 leukemic cells increases resistance to imatinib Homo sapiens