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Literature summary for 2.4.2.19 extracted from

  • Shibata, K.; Iwai, K.
    Crystalline quinolinate phosphoribosyltransferase from Alcaligenes eutrophus subsp. quinolinicus: effects of metal ions, phosphorous-compounds, niacin nucleotides and glycerol (1980), Agric. Biol. Chem., 44, 119-123.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
glycerol glycerol markedly activates enzyme activity at pH 6.1 and pH 6.5, inhibition above pH 7.0, inhibition is strongest at pH 9.0 Cupriavidus necator

Inhibitors

Inhibitors Comment Organism Structure
5-phosphoribosyl-1-diphosphate
-
Cupriavidus necator
ADP 1 mM, 12% inhibition Cupriavidus necator
ATP 1 mM, 22% inhibition; inhibition is completely recovered by raising Mg2+ concentration Cupriavidus necator
Cd2+
-
Cupriavidus necator
CDP 1 mM, 13% inhibition Cupriavidus necator
Co2+
-
Cupriavidus necator
CTP 1 mM, 30% inhibition Cupriavidus necator
Cu2+
-
Cupriavidus necator
dTDP 1 mM, 14% inhibition Cupriavidus necator
dTTP 1 mM, 29% inhibition Cupriavidus necator
glycerol glycerol markedly activates enzyme activity at pH 6.1 and 6.5, inhibition above pH 7.0, inhibition is strongest at pH 9.0 Cupriavidus necator
GTP 1 mM, 17% inhibition Cupriavidus necator
Hg2+
-
Cupriavidus necator
ITP 1 mM, 24% inhibition Cupriavidus necator
Na4P2O7 3 mM, complete inhibition Cupriavidus necator
Ni2+
-
Cupriavidus necator
nicotinate mononucleotide 1 mM, 46% inhibition Cupriavidus necator
UTP 1 mM, 19% inhibition Cupriavidus necator
Zn2+
-
Cupriavidus necator

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.051
-
quinolinic acid in presence of 30% glycerol Cupriavidus necator
0.057
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Cupriavidus necator
0.091
-
quinolinate
-
Cupriavidus necator
0.128
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Cupriavidus necator

Organism

Organism UniProt Comment Textmining
Cupriavidus necator
-
subsp. quinolinicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Cupriavidus necator nicotinate D-ribonucleotide + diphosphate + CO2
-
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Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information turnover rate is decreased by adding glycerol Cupriavidus necator

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0838
-
nicotinate mononucleotide
-
Cupriavidus necator
0.265
-
5-phosphoribosyl-1-diphosphate
-
Cupriavidus necator