Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glycerol | glycerol markedly activates enzyme activity at pH 6.1 and pH 6.5, inhibition above pH 7.0, inhibition is strongest at pH 9.0 | Cupriavidus necator |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-phosphoribosyl-1-diphosphate | - |
Cupriavidus necator | |
ADP | 1 mM, 12% inhibition | Cupriavidus necator | |
ATP | 1 mM, 22% inhibition; inhibition is completely recovered by raising Mg2+ concentration | Cupriavidus necator | |
Cd2+ | - |
Cupriavidus necator | |
CDP | 1 mM, 13% inhibition | Cupriavidus necator | |
Co2+ | - |
Cupriavidus necator | |
CTP | 1 mM, 30% inhibition | Cupriavidus necator | |
Cu2+ | - |
Cupriavidus necator | |
dTDP | 1 mM, 14% inhibition | Cupriavidus necator | |
dTTP | 1 mM, 29% inhibition | Cupriavidus necator | |
glycerol | glycerol markedly activates enzyme activity at pH 6.1 and 6.5, inhibition above pH 7.0, inhibition is strongest at pH 9.0 | Cupriavidus necator | |
GTP | 1 mM, 17% inhibition | Cupriavidus necator | |
Hg2+ | - |
Cupriavidus necator | |
ITP | 1 mM, 24% inhibition | Cupriavidus necator | |
Na4P2O7 | 3 mM, complete inhibition | Cupriavidus necator | |
Ni2+ | - |
Cupriavidus necator | |
nicotinate mononucleotide | 1 mM, 46% inhibition | Cupriavidus necator | |
UTP | 1 mM, 19% inhibition | Cupriavidus necator | |
Zn2+ | - |
Cupriavidus necator |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.051 | - |
quinolinic acid | in presence of 30% glycerol | Cupriavidus necator | |
0.057 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Cupriavidus necator | |
0.091 | - |
quinolinate | - |
Cupriavidus necator | |
0.128 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Cupriavidus necator |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cupriavidus necator | - |
subsp. quinolinicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Cupriavidus necator | nicotinate D-ribonucleotide + diphosphate + CO2 | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | turnover rate is decreased by adding glycerol | Cupriavidus necator |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0838 | - |
nicotinate mononucleotide | - |
Cupriavidus necator | |
0.265 | - |
5-phosphoribosyl-1-diphosphate | - |
Cupriavidus necator |