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Literature summary for 2.4.2.19 extracted from

  • Taguchi, H.; Iwai, K.
    Properties of the crystalline quinolinate phosphoribosyltransferase from hog liver (1975), Agric. Biol. Chem., 39, 1599-1604.
No PubMed abstract available
Search for more literature for 2.4.2.19

Inhibitors

Inhibitors Comment Organism Structure
Ag+ 1 mM, complete inhibition Sus scrofa
Al3+ 1 mM, 82.8% inhibition Sus scrofa
Ba2+ 1 mM, 38.1% inhibition Sus scrofa
Ca2+ 1 mM, 34.9% inhibition Sus scrofa
Cd2+ 1 mM, 75.5% inhibition Sus scrofa
Co2+ 1 mM, 65.2% inhibition Sus scrofa
Cr3+ 1 mM, 46.4% inhibition Sus scrofa
Cu2+ 1 mM, 86.9% inhibition Sus scrofa
Fe2+ 1 mM, 61.5% inhibition Sus scrofa
Fe3+ 1 mM, 92.9% inhibition Sus scrofa
Hg2+ 1 mM, 99.9% inhibition Sus scrofa
Mg2+ 1 mM, 7.7% inhibition Sus scrofa
Mn2+ 1 mM, 80.3% inhibition Sus scrofa
Ni2+ 1 mM, 76.5% inhibition Sus scrofa
Sr2+ 47.6% inhibition Sus scrofa
Zn2+ 1 mM, 82.1% inhibition Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
 quinolinate
-
 Sus scrofa
0.18
-
 5-phospho-alpha-D-ribose 1-diphosphate
-
 Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ can partially replace Mg2+ Sus scrofa
Co2+ can partially replace Mg2+ Sus scrofa
Mg2+ divalent cation required, Mg2+ is most effective at 1 mM Sus scrofa
Zn2+ can partially replace Mg2+ Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa intermediary enzyme in the de novo NAD biosynthetic pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information intermediary enzyme in the de novo NAD biosynthetic pathway Sus scrofa ?
-
 ?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Sus scrofa nicotinate D-ribonucleotide + diphosphate + CO2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.1
-
-
 Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
5.2 7.8 half maximal activity at pH 5.2 and pH 7.8 Sus scrofa