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Literature summary for 2.4.2.19 extracted from
- The enzymatic conversion of quinolinate to nicotinic acid mononucleotide in mammalian liver (1964), J. Biol. Chem., 239, 1208-1214.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Tris | - |
Bos taurus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
nicotinic acid | - |
Bos taurus | |
| 0.05 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Bos taurus | |
| 0.06 | - |
quinolinate | - |
Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | monovalent cation required, K+, Li+ or NH4+ markedly stimulate | Bos taurus | |
| Li+ | monovalent cation required, K+, Li+ or NH4+ markedly stimulate | Bos taurus | |
| Mg2+ | maximal activity at 0.1-0.2 mM | Bos taurus | |
| Mn2+ | half as effective as Mg2+ | Bos taurus | |
| NH4+ | monovalent cation required, K+, Li+ or NH4+ markedly stimulate | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.073 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O | - |
Bos taurus | beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | - |
? | |
| pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Bos taurus | nicotinate D-ribonucleotide + diphosphate + CO2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | - |
- |
Bos taurus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.4 | 7.3 | pH 6.4: about 50% of maximal activity, pH 7.3: about 55% of maximal activity | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | 0.1 mM, 75% inhibition | Bos taurus | |
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Release 2023.1 (January 2023)
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