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Literature summary for 2.4.2.17 extracted from

  • Jiao, W.; Mittelstaedt, G.; Moggre, G.J.; Parker, E.J.
    Hinge twists and population shifts deliver regulated catalysis for ATP-PRT in histidine biosynthesis (2019), Biophys. J., 116, 1887-1897.
    View publication on PubMed
Search for more literature for 2.4.2.17

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Campylobacter jejuni

Protein Variants

Protein Variants Comment Organism
R216A the mutant shows more than 50% inhibition at 0.25 mM AMP and complete loss of response to histidine while retaining its histidine-binding ability Campylobacter jejuni
R216Q the mutant shows about 50% inhibition at 0.25 mM AMP, about 20% inhibition at 0.025 mM L-histidine, and about 45% inhibition at 0.25 mM ATP plus 0.025 mM L-histidine Campylobacter jejuni

Inhibitors

Inhibitors Comment Organism Structure
AMP about 10% inhibition at 0.25 mM Campylobacter jejuni
L-histidine complete inhibition at 1 mM, about 10% inhibition at 0.25 mM Campylobacter jejuni

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on, 10 mM used in assay conditions Campylobacter jejuni

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate Campylobacter jejuni
-
 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate Campylobacter jejuni RM1221
-
 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Campylobacter jejuni
-
 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Campylobacter jejuni RM1221
-
 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni Q5HSJ4
-
-
Campylobacter jejuni RM1221 Q5HSJ4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Campylobacter jejuni

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 Campylobacter jejuni ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 Campylobacter jejuni RM1221 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Campylobacter jejuni 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Campylobacter jejuni RM1221 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r

Synonyms

Synonyms Comment Organism
ATP-phosphoribosyltransferase
-
 Campylobacter jejuni
ATP-PRT
-
 Campylobacter jejuni