Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.17 extracted from

  • Fisher, G.; Thomson, C.M.; Stroek, R.; Czekster, C.M.; Hirschi, J.S.; da Silva, R.G.
    Allosteric activation shifts the rate-limiting step in a short-form ATP phosphoribosyltransferase (2018), Biochemistry, 57, 4357-4367.
    View publication on PubMed
Search for more literature for 2.4.2.17

Inhibitors

Inhibitors Comment Organism Structure
ADP orthosteric inhibition Psychrobacter arcticus
AMP AMP is an inhibitor of subunit HisGS Psychrobacter arcticus
L-histidine in the presence of histidine, subunit HisZ mediates allosteric inhibition of the enzyme Psychrobacter arcticus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on, 15 mM used in assay conditions Psychrobacter arcticus
Mn2+ replacement of Mg2+ by Mn2+ enhances catalysis by subunit HisGS but not by the holoenzyme Psychrobacter arcticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Psychrobacter arcticus
-
 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Psychrobacter arcticus DSM 17307
-
 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate Psychrobacter arcticus
-
 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate Psychrobacter arcticus DSM 17307
-
 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Organism

Organism UniProt Comment Textmining
Psychrobacter arcticus Q4FQF7
-
-
Psychrobacter arcticus DSM 17307 Q4FQF7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Psychrobacter arcticus N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Psychrobacter arcticus DSM 17307 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 Psychrobacter arcticus ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 Psychrobacter arcticus DSM 17307 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Subunits

Subunits Comment Organism
heterooctamer short-form ATP phosphoribosyltransferase is a hetero-octameric allosteric enzyme comprising four catalytic subunits (HisGS) and four regulatory subunits (HisZ) Psychrobacter arcticus

Synonyms

Synonyms Comment Organism
adenosine 5'-triphosphate phosphoribosyltransferase
-
 Psychrobacter arcticus
ATPPRT
-
 Psychrobacter arcticus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.079
-
 subunit HisGS, at 20°C, pH not specified in the publication Psychrobacter arcticus AMP