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Literature summary for 2.4.2.17 extracted from

  • Fisher, G.; Thomson, C.M.; Stroek, R.; Czekster, C.M.; Hirschi, J.S.; da Silva, R.G.
    Allosteric activation shifts the rate-limiting step in a short-form ATP phosphoribosyltransferase (2018), Biochemistry, 57, 4357-4367 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.17

Inhibitors

Inhibitors Comment Organism Structure
ADP orthosteric inhibition Psychrobacter arcticus
AMP AMP is an inhibitor of subunit HisGS Psychrobacter arcticus
L-histidine in the presence of histidine, subunit HisZ mediates allosteric inhibition of the enzyme Psychrobacter arcticus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on, 15 mM used in assay conditions Psychrobacter arcticus
Mn2+ replacement of Mg2+ by Mn2+ enhances catalysis by subunit HisGS but not by the holoenzyme Psychrobacter arcticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Psychrobacter arcticus
-
 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Psychrobacter arcticus DSM 17307
-
 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate Psychrobacter arcticus
-
 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate Psychrobacter arcticus DSM 17307
-
 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Organism

Organism UniProt Comment Textmining
Psychrobacter arcticus Q4FQF7
-
-
Psychrobacter arcticus DSM 17307 Q4FQF7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Psychrobacter arcticus N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Psychrobacter arcticus DSM 17307 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 Psychrobacter arcticus ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
 Psychrobacter arcticus DSM 17307 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Subunits

Subunits Comment Organism
heterooctamer short-form ATP phosphoribosyltransferase is a hetero-octameric allosteric enzyme comprising four catalytic subunits (HisGS) and four regulatory subunits (HisZ) Psychrobacter arcticus

Synonyms

Synonyms Comment Organism
adenosine 5'-triphosphate phosphoribosyltransferase
-
 Psychrobacter arcticus
ATPPRT
-
 Psychrobacter arcticus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.079
-
 subunit HisGS, at 20°C, pH not specified in the publication Psychrobacter arcticus AMP