Literature summary for 2.4.2.17 extracted from

Alphey, M.; Fisher, G.; Ge, Y.; Gould, E.; Machado, T.; Liu, H.; Florence, G.; Naismith, J.; Da Silva, R.
Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase (2018), ACS Catal., 8, 5601-5610.

No PubMed abstract available

Crystallization (Commentary)

Crystallization (Comment)	Organism
holoenzyme and catalytic subunit HisGS in complexes with substrates (5-phospho-alpha-D-ribose 1-diphosphate, 5-phospho-alpha-D-ribose 1-diphosphate-ATP, 5-phospho-alpha-D-ribose 1-diphosphate-ADP), product (N1-(5-phospho-beta-D-ribosyl)-ATP) and inhibitor (AMP), hanging drop vapor diffusion method, using 10% (w/v) polyethylene glycol 3350, 0.1 M bicine pH 8.5, 50 mM MgCl2, 0.1 M KBr, and 4% (v/v) 1,6-hexanediol	Psychrobacter arcticus

Crystallization (Comment)

Organism

holoenzyme and catalytic subunit HisGS in complexes with substrates (5-phospho-alpha-D-ribose 1-diphosphate, 5-phospho-alpha-D-ribose 1-diphosphate-ATP, 5-phospho-alpha-D-ribose 1-diphosphate-ADP), product (N1-(5-phospho-beta-D-ribosyl)-ATP) and inhibitor (AMP), hanging drop vapor diffusion method, using 10% (w/v) polyethylene glycol 3350, 0.1 M bicine pH 8.5, 50 mM MgCl2, 0.1 M KBr, and 4% (v/v) 1,6-hexanediol

Psychrobacter arcticus

Inhibitors

Inhibitors	Comment	Organism	Structure
AMP	-	Psychrobacter arcticus
L-histidine	-	Psychrobacter arcticus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	dependent on	Psychrobacter arcticus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate	Psychrobacter arcticus	-	N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate	-	r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate	Psychrobacter arcticus DSM 17307	-	N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate	-	r

Organism

Organism	UniProt	Comment	Textmining
Psychrobacter arcticus	Q4FQF7	-	-
Psychrobacter arcticus DSM 17307	Q4FQF7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate	-	Psychrobacter arcticus	N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate	-	r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate	-	Psychrobacter arcticus DSM 17307	N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate	-	r

Subunits

Subunits	Comment	Organism
heterooctamer	the enzyme consist of four catalytic subunits (HisGS) and four regulatory subunits (HisZ)	Psychrobacter arcticus

Synonyms

Synonyms	Comment	Organism
adenosine 5'-triphosphate phosphoribosyltransferase	-	Psychrobacter arcticus
ATPPRT	-	Psychrobacter arcticus
HisG	-	Psychrobacter arcticus