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Literature summary for 2.4.2.12 extracted from

  • Torretta, S.; Colombo, G.; Travelli, C.; Boumya, S.; Lim, D.; Genazzani, A.A.; Grolla, A.A.
    The cytokine nicotinamide phosphoribosyltransferase (eNAMPT; PBEF; visfatin) acts as a natural antagonist of C-C chemokine receptor type 5 (CCR5) (2020), Cells, 9, 496 .
    View publication on PubMed
Search for more literature for 2.4.2.12

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Mus musculus
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide D-ribonucleotide + diphosphate Mus musculus
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
nicotinamide D-ribonucleotide + diphosphate Homo sapiens
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-
Mus musculus Q99KQ4
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA resin column chromatography Mus musculus
Ni-NTA resin column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-16 cell
-
 Mus musculus
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme binds to the C-C chemokine receptor type 5 and acts as a natural antagonist of this receptor Mus musculus ?
-
-
additional information the enzyme binds to the C-C chemokine receptor type 5 and acts as a natural antagonist of this receptor Homo sapiens ?
-
-
nicotinamide D-ribonucleotide + diphosphate
-
 Mus musculus nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
nicotinamide D-ribonucleotide + diphosphate
-
 Homo sapiens nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
eNAMPT
-
 Mus musculus
eNAMPT
-
 Homo sapiens
extracellular nicotinamide phosphoribosyltrasferase
-
 Mus musculus
extracellular nicotinamide phosphoribosyltrasferase
-
 Homo sapiens
PBEF
-
 Mus musculus
PBEF
-
 Homo sapiens
Visfatin
-
 Mus musculus
Visfatin
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme inhibits Rantes-induced Ca2+-rises and Rantes-induced migration in melanoma cells Mus musculus
physiological function the enzyme inhibits Rantes-induced Ca2+-rises and Rantes-induced migration in melanoma cells Homo sapiens