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Literature summary for 2.4.2.12 extracted from

  • Zhang, L.Q.; Van Haandel, L.; Xiong, M.; Huang, P.; Heruth, D.P.; Bi, C.; Gaedigk, R.; Jiang, X.; Li, D.Y.; Wyckoff, G.; Grigoryev, D.N.; Gao, L.; Li, L.; Wu, M.; Leeder, J.S.; Ye, S.Q.
    Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase (2017), Cell Death Dis., 8, e2705 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide D-ribonucleotide + diphosphate Mus musculus
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q99KQ4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide D-ribonucleotide + diphosphate
-
 Mus musculus nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 56000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
Nampt
-
 Mus musculus

General Information

General Information Comment Organism
malfunction homozygous enzyme knockout results in lethality at an early stage of mouse embryonic development and death within 5-10 days in adult mice accompanied by a 25.24% body weight loss Mus musculus
physiological function the enzyme is an essential gene for adult mouse survival. The enzyme is involved in key basic cellular functions such as transcription, translation, cell signaling, and fundamental metabolism Mus musculus