Literature summary for 2.4.2.12 extracted from

Zabka, T.S.; Singh, J.; Dhawan, P.; Liederer, B.M.; Oeh, J.; Kauss, M.A.; Xiao, Y.; Zak, M.; Lin, T.; McCray, B.; La, N.; Nguyen, T.; Beyer, J.; Farman, C.; Uppal, H.; Dragovich, P.S.; OBrien, T.; Sampath, D.; Misner, D.L.
Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase (2015), Toxicol. Sci., 144, 163-172.

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Inhibitors

Inhibitors	Comment	Organism	Structure
APO866	formerly FK866	Homo sapiens
APO866	formerly FK866	Rattus norvegicus
GMX-1778	formerly CHS-828	Homo sapiens
GMX-1778	formerly CHS-828	Rattus norvegicus
GNE-617	-	Homo sapiens
GNE-618	-	Homo sapiens
GNE-643	-	Homo sapiens
GNE-875	-	Homo sapiens
N-(4-[[3-(trifluoromethyl)phenyl]sulfonyl]benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide	-	Homo sapiens
N-(4-[[3-(trifluoromethyl)phenyl]sulfonyl]benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide	-	Rattus norvegicus
N-[(5-[[3-(trifluoromethyl)phenyl]sulfonyl]pyridin-2-yl)methyl]furo[2,3-c]pyridine-2-carboxamide	-	Homo sapiens
N-[(5-[[3-(trifluoromethyl)phenyl]sulfonyl]pyridin-2-yl)methyl]furo[2,3-c]pyridine-2-carboxamide	-	Rattus norvegicus
N-[4-[(3,5-difluorophenyl)sulfonyl]benzyl]imidazo[1,2-a]pyridine-6-carboxamide	-	Homo sapiens
N-[4-[(3,5-difluorophenyl)sulfonyl]benzyl]imidazo[1,2-a]pyridine-6-carboxamide	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate	Rattus norvegicus	-	nicotinamide D-ribonucleotide + diphosphate	-	?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate	Homo sapiens	-	nicotinamide D-ribonucleotide + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P43490	-	-
Rattus norvegicus	Q80Z29	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-2780 cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-
HT-1080 cell	-	Homo sapiens	-
PC-3 cell	-	Homo sapiens	-
retinal pigment epithelium cell	-	Rattus norvegicus	-
retinal pigment epithelium cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate	-	Rattus norvegicus	nicotinamide D-ribonucleotide + diphosphate	-	?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate	-	Homo sapiens	nicotinamide D-ribonucleotide + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
Nampt	-	Rattus norvegicus
Nampt	-	Homo sapiens

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Release 2023.1 (January 2023)