Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1Z)-N'-(benzoyloxy)-3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanimidamide | - |
Homo sapiens | |
(2R,2'R)-5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-2,2',3,3'-tetrahydro-4H,4'H-[3,8'-bi-1-benzopyran]-4,4'-dione | - |
Homo sapiens | |
1-(pyridin-3-ylmethyl)-3-[4-(pyrrolidin-1-ylsulfonyl)phenyl]thiourea | - |
Homo sapiens | |
1-[3-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea | potent inhibitor | Homo sapiens | |
1-[4-(morpholin-4-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea | - |
Homo sapiens | |
1-[4-(piperazin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea | - |
Homo sapiens | |
1-[4-(piperidin-1-ylcarbonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea | - |
Homo sapiens | |
1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)guanidine | - |
Homo sapiens | |
1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)urea | - |
Homo sapiens | |
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)guanidine | - |
Homo sapiens | |
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea | - |
Homo sapiens | |
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-4-ylmethyl)thiourea | - |
Homo sapiens | |
1-[4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-3-(pyridin-3-ylmethyl)thiourea | - |
Homo sapiens | |
4-chloro-N-[(5-[[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]sulfamoyl]thiophen-2-yl)methyl]benzamide | - |
Homo sapiens | |
ethyl [(E)-[4-(piperidine-1-sulfonyl)anilino][[(pyridin-3-yl)methyl]amino]methylidene]carbamate | - |
Homo sapiens | |
N-(4-[4-[(1H-benzimidazol-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(2,6-difluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(2-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(2-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(2-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(3-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(3-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(3-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(4-aminophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(4-bromophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(4-butylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(4-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(4-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(4-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(4-nitrophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(furan-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(furan-3-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-(4-[4-[(naphthalen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-benzyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide | - |
Homo sapiens | |
N-phenyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide | - |
Homo sapiens | |
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea | - |
Homo sapiens | |
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-4-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea | - |
Homo sapiens | |
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea | - |
Homo sapiens | |
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea | - |
Homo sapiens | |
N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethoxy)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea | - |
Homo sapiens | |
N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea | - |
Homo sapiens | |
N-[(pyridin-3-yl)methyl]-N'-[4-[4-(pyridin-2-yl)piperazine-1-sulfonyl]phenyl]thiourea | - |
Homo sapiens | |
N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzothiophene-2-carboxamide | - |
Homo sapiens | |
N-[4-(4-acetylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-[4-(4-benzylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-[4-(4-cyclohexylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
N-[4-[(4E)-4-(2,3-dimethoxybenzylidene)-5-oxo-4,5-dihydro-1,3-oxazol-2-yl]phenyl]thiophene-2-carboxamide | - |
Homo sapiens | |
N-[4-[4-(4-methylphenyl)piperazine-1-sulfonyl]phenyl]-N'-[(pyridin-3-yl)methyl]thiourea | - |
Homo sapiens | |
tert-butyl 4-[4-([[(pyridin-3-yl)methyl]carbamothioyl]amino)benzene-1-sulfonyl]piperazine-1-carboxylate | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
x * 55000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
nicotinamide D-ribonucleotide + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
95-D cell | - |
Homo sapiens | - |
A-2780 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
U2OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | nicotinamide D-ribonucleotide + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 55000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Nampt | - |
Homo sapiens |
pre-B cell colony enhancing factor | - |
Homo sapiens |
Visfatin | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000009 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[4-(4-benzylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000089 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(3-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000098 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea | |
0.0000099 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(2,6-difluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000105 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(4-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.000012 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(4-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000123 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(2-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000124 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(2-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000126 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(3-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000137 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(4-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000137 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-4-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea | |
0.000014 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(1H-benzimidazol-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000142 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[4-(4-cyclohexylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000154 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[4-[4-(4-methylphenyl)piperazine-1-sulfonyl]phenyl]-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000157 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(2-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000168 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(3-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000177 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[(pyridin-3-yl)methyl]-N'-[4-[4-(pyridin-2-yl)piperazine-1-sulfonyl]phenyl]thiourea | |
0.0000191 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(furan-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000196 | - |
at pH 7.5 and 37°C | Homo sapiens | N-benzyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide | |
0.0000197 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(4-nitrophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000199 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(4-aminophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000201 | - |
at pH 7.5 and 37°C | Homo sapiens | 1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea | |
0.0000217 | - |
at pH 7.5 and 37°C | Homo sapiens | tert-butyl 4-[4-([[(pyridin-3-yl)methyl]carbamothioyl]amino)benzene-1-sulfonyl]piperazine-1-carboxylate | |
0.0000217 | - |
at pH 7.5 and 37°C | Homo sapiens | 1-[4-(morpholin-4-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea | |
0.000022 | - |
at pH 7.5 and 37°C | Homo sapiens | N-phenyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide | |
0.0000225 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea | |
0.0000237 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea | |
0.0000242 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(4-bromophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000295 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(naphthalen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000369 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethoxy)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea | |
0.0000388 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea | |
0.0000405 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[4-(4-acetylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000422 | - |
at pH 7.5 and 37°C | Homo sapiens | 1-[4-(piperidin-1-ylcarbonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea | |
0.0000439 | - |
at pH 7.5 and 37°C | Homo sapiens | 1-(pyridin-3-ylmethyl)-3-[4-(pyrrolidin-1-ylsulfonyl)phenyl]thiourea | |
0.0000487 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(furan-3-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000798 | - |
at pH 7.5 and 37°C | Homo sapiens | N-(4-[4-[(4-butylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea | |
0.0000845 | - |
at pH 7.5 and 37°C | Homo sapiens | 1-[4-(piperazin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea | |
0.0000964 | - |
at pH 7.5 and 37°C | Homo sapiens | 1-[4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-3-(pyridin-3-ylmethyl)thiourea | |
0.0000989 | - |
at pH 7.5 and 37°C | Homo sapiens | 1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)urea | |
0.000765 | - |
at pH 7.5 and 37°C | Homo sapiens | 1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)guanidine | |
0.00987 | - |
at pH 7.5 and 37°C | Homo sapiens | 1-[3-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea | |
0.01453 | - |
at pH 7.5 and 37°C | Homo sapiens | 1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)guanidine | |
0.149 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzothiophene-2-carboxamide | |
0.166 | - |
at pH 7.5 and 37°C | Homo sapiens | ethyl [(E)-[4-(piperidine-1-sulfonyl)anilino][[(pyridin-3-yl)methyl]amino]methylidene]carbamate | |
0.504 | - |
at pH 7.5 and 37°C | Homo sapiens | (2R,2'R)-5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-2,2',3,3'-tetrahydro-4H,4'H-[3,8'-bi-1-benzopyran]-4,4'-dione | |
0.855 | - |
at pH 7.5 and 37°C | Homo sapiens | (1Z)-N'-(benzoyloxy)-3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanimidamide | |
4.162 | - |
at pH 7.5 and 37°C | Homo sapiens | 4-chloro-N-[(5-[[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]sulfamoyl]thiophen-2-yl)methyl]benzamide | |
6.443 | - |
at pH 7.5 and 37°C | Homo sapiens | N-[4-[(4E)-4-(2,3-dimethoxybenzylidene)-5-oxo-4,5-dihydro-1,3-oxazol-2-yl]phenyl]thiophene-2-carboxamide |