Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FK866 | specific and potent inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
nicotinamide D-ribonucleotide + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P43490 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-2780 cell | - |
Homo sapiens | - |
BxPC-3 cell | - |
Homo sapiens | - |
culture condition:McCoys 5A medium-grown cell | - |
Homo sapiens | - |
DLD-1 cell | - |
Homo sapiens | - |
HCC-1937 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
SUM-149 cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | nicotinamide D-ribonucleotide + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Nampt | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition is responsible for ATP depletion, metabolic perturbation, and subsequent tumor growth inhibition | Homo sapiens |
physiological function | the enzyme catalyzes the first rate-limiting step in converting nicotinamide to NAD+, essential for cellular metabolism, energy production, and DNA repair | Homo sapiens |