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Literature summary for 2.4.2.12 extracted from

  • Hara, N.; Yamada, K.; Shibata, T.; Osago, H.; Tsuchiya, M.
    Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma (2011), PLoS ONE, 6, e22781.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
ATP essential activator Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00051
-
5-phosphoribosyl 1-diphosphate with 1 mM ATP, pH 7.5, 37°C Homo sapiens
0.00122
-
nicotinamide with 1 mM ATP, pH 7.5, 37°C Homo sapiens
0.00806
-
nicotinamide without ATP, pH 7.5, 37°C Homo sapiens
0.0232
-
5-phosphoribosyl 1-diphosphate without ATP, pH 7.5, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00213
-
at 0.001 mM 5-phosphoribosyl 1-diphosphate, without ATP, pH 7.5, 37°C Homo sapiens
0.0259
-
at 0.050 mM 5-phosphoribosyl 1-diphosphate, without ATP, pH 7.5, 37°C Homo sapiens
0.0259
-
substrate 5-phosphoribosyl 1-diphosphate, without ATP, pH 7.5, 37°C Homo sapiens
0.0393
-
substrate nicotinamide, without ATP, pH 7.5, 37°C Homo sapiens
0.0397
-
substrate nicotinamide, with 1 mM ATP, pH 7.5, 37°C Homo sapiens
0.0481
-
at 0.050 mM 5-phosphoribosyl 1-diphosphate, with 1 mM ATP, pH 7.5, 37°C Homo sapiens
0.0704
-
at 0.001 mM 5-phosphoribosyl 1-diphosphate, with 1 mM ATP, pH 7.5, 37°C Homo sapiens
0.0741
-
substrate 5-phosphoribosyl 1-diphosphate, with 1 mM ATP, pH 7.5, 37°C Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phosphoribosyl 1-diphosphate
-
Homo sapiens nicotinamide mononucleotide + diphosphate
-
?

Synonyms

Synonyms Comment Organism
nicotinamide phosphoribosyltransferase
-
Homo sapiens
nicotinamide phosphoribosyltransferase/Visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma Homo sapiens